If you have been exposed to someone who has active TB, and the result of your skin test is “negative,” you most likely do not have TB germs in your body. You probably do not need to take medicine. However, in some instances your doctor may recommend treatment, even if the result of your skin test is negative. Also, someone whose immune system is weakened by chronic medical conditions may also be recommended to take medicine even though the TB skin test may not be positive.

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